Author

Takahisa Miyao

RIKEN Center for Integrative Medical Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Cell Biology· 1

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Research Focus:cell type annotation· 7 Approach:experimental assay· 6 Organism:mouse· 6 Research Focus:differential expression· 5 Research Focus:gene regulatory network inference· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Assay:scRNA-seq· 3

Frequent Co-Authors

Nobuko AkiyamaiD· 6 shared Taishin AkiyamaiD· 6 shared Hiroto Ishii· 5 shared Maki Miyauchi· 5 shared Naho Hagiwara· 5 shared Rin Endo· 5 shared Kano Namiki· 3 shared Masaki YoshidaiD· 3 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

Nobuko AkiyamaORCID

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7 papers

Recent·Most cited

Second impact of an acute total body irradiation on thymic epithelial cells

Kano Namiki, Wataru Muramatsu, Takahisa Miyao, Hiroto Ishii, Rin Endo, Naho Hagiwara, Maki Miyauchi, Masaki Yoshida, Nobuko Akiyama, Taishin Akiyama

This study investigates the second impact of acute total body irradiation on thymic epithelial cells, finding reduced mTEC frequencies and altered gene expression during the second impact phase.

Heliyon · Jul 1, 2026Peer-reviewedImmunology

Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for functional differentiation of Treg cells

Ryuichi Murakami, Norihito Hayatsu, Takahisa Miyao, Zhenan Liu, Yukito Kino, Shumpei Shibata, Suzu Kawagoe, Masashi Matsuda, Yusuke Iizuka, Hiroki Sugishita, Hideyuki Yoshida, Yoshinori Hasegawa, Wataru Ise, Haruhiko Koseki, Tomohiro Kurosaki, Shohei Hori

The paper identifies cooperative roles of Foxp3 and BATF in directing cis-regulatory programs and gene expression for Treg cell differentiation.

Immunity · Mar 30, 2026Peer-reviewedImmunology

A chromatin relay from AIRE to ETS transcription factors sustains peripheral antigen expression in the thymic mimetic cells to ensure central tolerance.

Kenta Horie, Takahisa Miyao, Yuko Yamagata, Yuki Takakura, Fuyoko Suzuki, Naho Hagiwara, Rin Endo, Maki Miyauchi, Hiroto Ishii, Wataru Muramatsu, Yuki Goda, Tatsuya Ishikawa, Jun‐ichiro Inoue, Nobuaki Yoshida, N Yamaguchi, , Taishin Akiyama

The paper identifies EHF and ELF3 as key ETS transcription factors that sustain AIRE-primed gene expression in post-AIRE mimetic thymic epithelial cells, ensuring central tolerance.

bioRxiv · Feb 5, 2026 · PreprintImmunology

TCR repertoire analysis quantifies effect of irradiation to homeostasis of iNKT cell development in the thymus of mice

Kazumasa B. Kaneko, Mio Hayama, Nanako Uchida, Takahisa Miyao, Nobuko Akiyama, Taishin Akiyama, Tetsuya J. Kobayashi

The paper quantifies how irradiation affects iNKT cell development in the thymus of mice by analyzing TCR repertoire changes and recovery dynamics.

Genes to Cells · Dec 22, 2025Peer-reviewedImmunology

ASCL1 primes medullary thymic epithelial cell programs required for central tolerance

Nobuko Akiyama, Kenta Horie, Kano Namiki, Jen-Chien Chang, Maki Miyauchi, Takahisa Miyao, Nanako Uchida, Naho Hagiwara, Masaki Yoshida, Mizuki Morota, Tsukasa Kouno, Miki Kojima, Jonathan Moody, Yoshinari Ando, Hirotake Ichise, , Taishin Akiyama

The paper identifies ASCL1 as a key regulator of mTEC function and central tolerance by analyzing single-cell RNA sequencing data from thymoma patients and mouse models.

bioRxiv · Aug 6, 2025 · PreprintImmunology

Direct and indirect RANK ligand and CD40 ligand signaling regulate the maintenance of thymic epithelial cell frequency and properties in the adult thymus

Mio Hayama, Hiroto Ishii, Maki Miyauchi, Masaki Yoshida, Naho Hagiwara, Wataru Muramtatu, Kano Namiki, Rin Endo, Takahisa Miyao, Nobuko Akiyama, Taishin Akiyama

This study shows that RANKL and CD40L signaling maintain mTEC frequency and TEC progenitor properties in the adult thymus through direct and indirect mechanisms.

Frontiers in Immunology · Nov 29, 2024Peer-reviewedImmunology

Establishing a method for the cryopreservation of viable peripheral blood mononuclear cells in the International Space Station

Hiroto Ishii, Rin Endo, Sanae Hamanaka, Nobuyuki Hidaka, Maki Miyauchi, Naho Hagiwara, Takahisa Miyao, Tohru Yamamori, Tatsuya Aiba, Nobuko Akiyama, Taishin Akiyama

This study develops a cryopreservation method for blood cells under ISS constraints, demonstrating viability recovery and subset analysis using flow cytometry.

bioRxiv · Mar 12, 2024 · PreprintCell Biology