Alignment-free phylogenetic inference via hyperbolic protein language models
yongtao Shan, Pan Fang, Yuqi Liu, Yuanfei Pan, Kaijie Liu, Yong He, Xue Liu, Weichen Wu, Guirong Xue, Jian He, Deyin Guo, Jianguo He, Edward Charles Holmes, Mǎng Shī, Zhaorong Li
LucaPhylo infers phylogenetic trees from unaligned protein sequences using hyperbolic geometry and protein language models, achieving accuracy comparable to alignment-based methods for divergent RNA viruses.
bioRxiv · May 29, 2026 · PreprintEvolutionary Biology