Jianguo He

LucaVirus predicts viral evolution and function using a unified nucleotide-protein language model, achieving state-of-the-art results in key virology tasks.

LucaPhylo infers phylogenetic trees from unaligned protein sequences using hyperbolic geometry and protein language models, achieving accuracy comparable to alignment-based methods for divergent RNA viruses.

This study shows that mutating the Gn1a gene in rice increases cytokinin levels, which enhances fish growth and immunity by altering soil microbiota and gut microbial composition.

This study shows that ISKNV-pORF71 hijacks VDAC2 from mitochondria to the nucleus, disrupting mitochondrial membrane permeability and enhancing apoptosis during infection.

The paper identifies RNA viruses in water shaping shrimp and fish viromes in aquaculture, showing strong correlations and shared species between water and aquatic animals.

This study identifies mfTfR1 as the entry receptor for SDDV, demonstrating its role in clathrin-mediated endocytosis and viral entry.

This study identifies wsv100 as a WSSV protein that inhibits the NF-kappaB pathway in shrimp, suppressing immune responses and enhancing viral replication.

This study uses single-cell RNA sequencing to analyze the response of mandarin fish pyloric caecum to MRV infection, revealing serositis as the cause of ascites.

This study shows SDDV induces ferroptosis by targeting TfR1, enhancing viral infection, and suggests ferroptosis inhibition as a therapeutic strategy.

This study uses single-cell RNA sequencing to analyze hemocyte subpopulations in shrimp infected with DIV1, identifying transcriptional heterogeneity, differentiation trajectories, and antiviral immune responses.

This study identifies CNPY3 as an antiviral mediator suppressed by flaviviruses via HuR-mediated mRNA destabilization and demonstrates LNP-CNPY3 as a therapeutic approach to enhance antiviral responses.

This study identifies peripheral B lymphocytes as a viral reservoir for persistent and covert Mandarinfish Ranavirus (MRV) infection, revealing a unique reactivation mechanism distinct from other ranaviruses.

This study shows that elevated temperatures enhance antiviral defenses in arthropods by activating HSF1 to upregulate antimicrobial peptides targeting viral envelopes.

This study reports the genome of Ridgeia piscesae, revealing that small genome size and positive selection on cell proliferation genes contribute to its high growth rates in deep-sea environments.

The paper identifies structural variants and H3K4me3 domains in two closely related fish species, showing their role in cis-regulatory divergence and phenotypic traits like metabolism and immunity.

This study reports the genome of Chiridota heheva, a deep-sea echinoderm, and identifies gene expansions and positive selection related to adaptation to reducing environments.

This study identifies penaeidins as antiviral effectors in shrimp that bind WSSV virions, inhibit viral entry, and are regulated by Toll and IMD pathways.

This study identifies a mitochondrial gene, OG1, capable of CO2 capture in engineered microorganisms, suggesting its potential for mitigating global warming through biological CO2 capture in barren lands.