Targeted α-Synuclein mRNA Degradation by PMO-Based RNA-Degrading Chimeras
Ning Wang, Shalakha Hegde, Zhichao Tang, Haiqing Liu, Gang Ling Feng, Lili Niu, Hanyu Li, Xiaodi Zhang, Kundlik Gadhave, Ramhari Kumbhar, Lan Jiang, Yuqi Liu, Maxwell Luo, Shu Zhang, Ted M. Dawson, , Jingxin Wang
This paper develops PMO-based RNA-degrading chimeras that target SNCA mRNA to reduce α-synuclein levels and prevent pathological aggregation in vitro and in vivo.
Proceedings of the National Academy of Sciences · Jul 14, 2026Peer-reviewedBiochemistry