UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
Jiandong Sun, Yan Liu, Yousheng Jia, Jennifer Tran, Xiaoning Hao, Weiju Lin, GARY S. LYNCH, Michel Baudry, Xiaoning Bi
This study shows that UBE3A regulates mTORC1 activity and synaptic plasticity by ubiquitinating and degrading p18, a Ragulator subunit, in Angelman syndrome mice.
eLife · Jul 18, 2018Peer-reviewedNeuroscience