GARY S. LYNCH

This study shows early-life oxytocin treatment reduces seizure susceptibility in male but not female Fmr1-KO mice, revealing sex-specific effects.

The paper investigates signal throughput in the hippocampal circuit, finding that single pulses and theta-modulated bursts are transmitted, while high-frequency inputs are filtered.

The paper shows sex-specific roles of metabotropic NMDA receptor signaling in synaptic plasticity and episodic memory in mice.

The paper shows that microglia depletion selectively impairs a specific form of hippocampal long-term potentiation (LTP) in the lateral perforant path.

The paper derives input-output transformation functions for hippocampal CA3 to CA1 synapses using Volterra expansion, revealing timing rules and differences between apical and basal dendrites.

The paper investigates how the SynGAP-1 PBM regulates NMDA receptor signaling and cognitive function in mice, finding that disrupting the PBM leads to synaptic and cognitive impairments.

This study shows that hippocampal CA3 maintains self-sustained activity and is critical for acquiring temporal order in odor memory, but not odor identity or location.

This study shows that UBE3A regulates mTORC1 activity and synaptic plasticity by ubiquitinating and degrading p18, a Ragulator subunit, in Angelman syndrome mice.