Inhibition of GEF-H1-RhoA signaling in inflammation with a stapled peptide mimicry of the RhoA67-78 helix
Clara Gathmann, Tiansheng Liu, Shuhuai Yang, Weitong Cynthia Wang, A. W. Edith Chan, Karl Matter, Maria Susana Balda, David L. Selwood
The paper designs a stapled peptide stP5 that inhibits GEF-H1-RhoA signaling in inflammation, showing 100-fold higher activity than the unstapled P5 peptide.
bioRxiv · Nov 18, 2024 · PreprintCell Biology