David L. Selwood

This study investigates allosteric capsid inhibitors and their resistance mutants, showing they trigger innate immune responses and may reduce HIV-1 transmission.

BG147 enhances lentivector transduction in HSPCs ex vivo and in mouse photoreceptors in vivo by degrading IFITM3.

This study identifies EPG5 mutations causing neurodegeneration via mitochondrial dysfunction and innate immune activation in patient-derived cells.

The paper designs a stapled peptide stP5 that inhibits GEF-H1-RhoA signaling in inflammation, showing 100-fold higher activity than the unstapled P5 peptide.

This paper introduces ULK1-Recruiting Chimeras (ULKRECs) that induce ULK1-dependent mitophagy, showing efficacy in Parkinson's fibroblasts independent of the PRKN/PINK axis.

This paper corrects FKRP mutations in iPSCs using CRISPR/Cas9, restoring functional glycosylation of α-dystroglycan in cortical neurons and validating the role of FKRP in dystroglycanopathies.