A. W. Edith Chan

BG147 enhances lentivector transduction in HSPCs ex vivo and in mouse photoreceptors in vivo by degrading IFITM3.

This paper develops a logistic regression model to predict HIV1 integrase resistance to INSTIs using protein sequence and residue features, achieving performance comparable to more complex models.

The paper designs a stapled peptide stP5 that inhibits GEF-H1-RhoA signaling in inflammation, showing 100-fold higher activity than the unstapled P5 peptide.

This paper uses deep learning to analyze the co-evolutionary dynamics of L2 β-lactamases and their functional mechanisms.

This paper corrects FKRP mutations in iPSCs using CRISPR/Cas9, restoring functional glycosylation of α-dystroglycan in cortical neurons and validating the role of FKRP in dystroglycanopathies.