Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection
Xiaoqiang Chai, Longfei Hu, Yan Zhang, Weiyu Han, Lu Zhou, Ai‐Wu Ke, Jian Zhou, Guo‐Ming Shi, Nan Fang, Jia Fan, Jiabin Cai, Jue Fan, Fei Lan
In healthy human liver scRNA-seq, ACE2 is detected in 59.7% of cholangiocytes but 2.6% of hepatocytes, so 2019-nCoV may target bile duct cells rather than hepatocytes.
bioRxiv · Feb 3, 2020 · PreprintGenomics✦ In-depth digest