Jia Fan

GALILEO autonomously discovers therapeutic peptides by combining AI reasoning with lab experiments, identifying peptides that block membrane currents and modulate immune responses.

The paper identifies DOT1L as a suppressor of tumor intrinsic immunogenicity using CRISPR screens and shows its inhibition enhances immune response in mice.

This study identifies BRD8 as an epigenetic suppressor of tumor-intrinsic immunity in liver cancer, showing its depletion enhances immunogenicity and sensitizes tumors to immunotherapy.

This study identifies SMYD5 as a methyltransferase that modifies RPL40 K22me3, enhancing translation and promoting hepatocellular carcinoma.

In healthy human liver scRNA-seq, ACE2 is detected in 59.7% of cholangiocytes but 2.6% of hepatocytes, so 2019-nCoV may target bile duct cells rather than hepatocytes.

The paper profiles m6A and m6Am methylomes across 42 human and 16 mouse tissues, revealing tissue-specific patterns and cross-species conservation.

This study develops a 5-hydroxymethylcytosine (5hmC) diagnostic model from circulating cell-free DNA to detect hepatocellular carcinoma with high accuracy and prognostic value.