Jiabin Cai

The paper identifies DOT1L as a suppressor of tumor intrinsic immunogenicity using CRISPR screens and shows its inhibition enhances immune response in mice.

In healthy human liver scRNA-seq, ACE2 is detected in 59.7% of cholangiocytes but 2.6% of hepatocytes, so 2019-nCoV may target bile duct cells rather than hepatocytes.

The paper profiles m6A and m6Am methylomes across 42 human and 16 mouse tissues, revealing tissue-specific patterns and cross-species conservation.