Structural insights into the recognition and catalysis of tRNA by human NSUN2
Q. P. Hu, Wen Yang, Yunyun Yu, Ran Yi, Yutong Zhang, Leyuan Duan, Lei Wang, Fudong Li, Kaiming Zhang, Qingguo Gong, Shanshan Li
This study determines the structure of human NSUN2 in complex with tRNA substrates, revealing its mechanism of substrate recognition and catalytic specificity, and identifies a small-molecule inhibitor.
bioRxiv · Jan 11, 2026 · PreprintMolecular Biology