Sub-3 A resolution protein structure determination by single-particle cryo-EM at 100 keV
Dimple Karia, Fujiet Koh, Wen Yang, Victoria I. Cushing, Benjamin Basanta, Daniel B. Mihaylov, Sagar Khavnekar, Ondřej Vyroubal, Miloš Malínský, Ondřej Sháněl, Vojtěch Doležal, Jürgen M. Plitzko, Lingbo Yu, Gabriel C. Lander, Alexandru Radu Aricescu, , Abhay Kotecha
This paper demonstrates that a 100 keV cryo-TEM with advanced components can achieve sub-3 Å resolution structures of various proteins and viruses.
Structure · Jul 30, 2025Peer-reviewedBiophysics