Author

Yutong Zhang

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Ayushi AgrawaliD· 2 shared Dakota D. Mallen· 2 shared Erica S BradyiD· 2 shared Inma CobosiD· 2 shared Jessica Herbert· 2 shared Jia ShiniD· 2 shared Jorge J. PalopiD· 2 shared Kelli LauderdaleiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Ayushi AgrawalORCID

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Author profile →

3 papers

Recent·Most cited

Therapeutic targeting of fibrin-microglia interactions ameliorates Alzheimer disease-related hyperexcitability and brain network dysfunction

Kelli Lauderdale, Zhaoqi Yan, Andrew S. Mendiola, Yutong Zhang, Dakota D. Mallen, Pranav Nambiar, Erica S Brady, Stephanie R. Miller, Rosa Meza-Acevedo, Belinda Cabriga, Xueqiao Jiang, Nick Kaliss, Kevin Shen, Jia Shin, Jessica Herbert, , Jorge J. Palop

This study shows that blocking fibrin-microglia interactions reduces AD-related brain network dysfunction and behavioral issues in mice.

bioRxiv · May 6, 2026 · PreprintNeuroscience

Structural insights into the recognition and catalysis of tRNA by human NSUN2

Q. P. Hu, Wen Yang, Yunyun Yu, Ran Yi, Yutong Zhang, Leyuan Duan, Lei Wang, Fudong Li, Kaiming Zhang, Qingguo Gong, Shanshan Li

This study determines the structure of human NSUN2 in complex with tRNA substrates, revealing its mechanism of substrate recognition and catalytic specificity, and identifies a small-molecule inhibitor.

bioRxiv · Jan 11, 2026 · PreprintMolecular Biology

APOE4-Aβ synergy drives brain network dysfunction and neuronal lysosomal-ER proteostasis dysregulation in preclinical Alzheimer's disease

Jia Shin, Erica S Brady, Chun Chen, Kelli Lauderdale, Ayushi Agrawal, Yutong Zhang, Xueqiao Jiang, Pranav Nambiar, Jessica Herbert, Dakota D. Mallen, Katie K. Ly, Patrick S. Honma, Zhongyi Guo, Cathrine Sant, Reuben Thomas, , Jorge J. Palop

This study investigates how APOE4 and Aβ interact in preclinical Alzheimer's disease, finding their synergistic effects on neuronal proteostasis and network dysfunction.

bioRxiv · Nov 11, 2025 · PreprintNeuroscience