Shanshan Li

Structural insights into the recognition and catalysis of tRNA by human NSUN2

This study determines the structure of human NSUN2 in complex with tRNA substrates, revealing its mechanism of substrate recognition and catalytic specificity, and identifies a small-molecule inhibitor.

Structural insights into type I and type II Lamassu anti-phage systems

The paper presents cryo-EM structures of type I and II Lamassu systems from different bacteria, revealing their architecture and mechanism of DNA cleavage.

Template-based RNA structure prediction advanced through a blind code competition

The paper describes a Kaggle competition for RNA 3D structure prediction, showing that template-based methods can outperform deep learning approaches.

Blind Prediction of Complex Water and Ion Ensembles Around RNA in CASP16

This paper evaluates blind predictions of dynamic water and ion ensembles around RNA using cryo-EM densities from CASP16, finding that molecular dynamics approaches perform best.

Complex Water Networks Visualized through 2.2-2.3 Angstrom Cryogenic Electron Microscopy of RNA

Two Tetrahymena ribozyme cryo-EM maps (2.2 and 2.3 Å) reveal cross-validated ordered waters and Mg2+ ions, plus reproducible diffuse solvent density resembling molecular dynamics water networks.

Accelerating PERx Reaction Enables Covalent Nanobodies for Potent Neutralization of SARS-Cov-2 and Variants

This paper develops covalent nanobodies using a PERx mechanism to neutralize SARS-CoV-2 and variants with greatly increased potency.