Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain
Wenbi Wu, Pankaj Kumar, Chad A. Brautigam, Shih‐Chia Tso, Hamid R. Baniasadi, Daniel L. Kober, Marie‐Alda Gilles‐Gonzalez
The paper determines six structures of DosP, revealing how its heme-binding PAS domain regulates c-di-GMP phosphodiesterase activity through allosteric mechanisms.
Nature Communications · Nov 7, 2024Peer-reviewedBiochemistry