Daniel L. Kober

A domain-swapped proPC1/3 structure reveals a conformational checkpoint for ER export

The paper determines the structure of an immature proPC1/3 variant and identifies a conformational checkpoint for ER export, explaining the functional impact of PCSK1 mutations.

Choreography of human mitochondrial leaderless mRNA translation initiation

The paper investigates human mitochondrial translation initiation on leaderless mRNAs, revealing two pathways involving mtIF2 and fMet-tRNAMet, with implications for regulation by mtIF3.

A biochemical mechanism for Stu2/XMAP215-family microtubule polymerases

This study establishes a quantitative biochemical mechanism for Stu2/XMAP215-family microtubule polymerases, showing they operate like enzymes with TOG domains acting as tubulin-shuttling antennas.

Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain

The paper determines six structures of DosP, revealing how its heme-binding PAS domain regulates c-di-GMP phosphodiesterase activity through allosteric mechanisms.