BiochemistrybioRxivPreprint
A domain-swapped proPC1/3 structure reveals a conformational checkpoint for ER export
Pankaj Kumar, Phillip A. Hyon, Rishi Nixon…·Daniel L. Kober
The paper determines the structure of an immature proPC1/3 variant and identifies a conformational checkpoint for ER export, explaining the functional impact of PCSK1 mutations.
DOI 10.64898/2026.07.21.739776