3D genome remodelling underlies PU.1-dependent granulocyte maturation
Wendy Jia, Timothy M. Johanson, Aleksandar Dakic, Alexandra L. Garnham, Gordon K. Smyth, Stephen L. Nutt, Rhys S. Allan, Hannah D. Coughlan
This study shows that PU.1 regulates granulocyte maturation by controlling transcriptional programs and 3D chromatin architecture through its binding sites.
bioRxiv · Jul 21, 2026 · PreprintImmunology