Alexandra L. Garnham

3D genome remodelling underlies PU.1-dependent granulocyte maturation

This study shows that PU.1 regulates granulocyte maturation by controlling transcriptional programs and 3D chromatin architecture through its binding sites.

Regulation of Human Erythroferrone Expression

This study identifies the transcriptional regulatory mechanisms governing ERFE expression in human erythroblasts using genomic approaches.

ARAP2 regulates responses to interferon-gamma by restricting SOCS1

This study identifies ARAP2 as a regulator of IFN-gamma signaling by modulating SOCS1 function through a phosphorylation-dependent interaction.

Differentiation of Toxoplasma into latent forms is linked to central carbon metabolism and requires a GID/CTLH-type E3 ubiquitin ligase

This study identifies glucose-limiting conditions and a GID/CTLH-type E3 ubiquitin ligase as key factors in Toxoplasma differentiation into latent forms.

Transcriptomic alterations including p53 pathway dysregulation prime DNMT3A mutant cells for transformation

This study shows DNMT3A mutations reduce DNA methylation and disrupt p53 pathway, increasing self-renewal and cancer risk in hematopoietic cells.

Expression of the Close homolog of L-1 and embigin identifies activated myofibroblasts.

The paper identifies ChL-1 and embigin as novel markers for activated myofibroblasts, showing their expression in fibrotic tissues and their utility for targeting these cells.

Clonal analysis of fetal hematopoietic stem/progenitor cell subsets reveals how post-transplantation capabilities are distributed

The paper compares functional properties of fetal and adult hematopoietic stem/progenitor cells through transplantation, revealing differences in lineage bias and clonal multi-lineage differentiation.

Suv39h-catalysed H3K9me3 is critical for euchromatic genome organisation and the maintenance of gene transcription

This study shows that Suv39h enzymes are essential for organizing euchromatic regions and maintaining gene transcription by tethering H3K9me3 domains to the nuclear lamina.

Activation-induced re-organization of chromatin in human T cells

This study examines how T cell activation alters chromatin structure and gene expression, identifying changes in chromatin interactions and domain organization.

Impaired social behaviour and molecular mediators of associated neural circuits during chronic Toxoplasma gondii infection in female mice

This study examines how chronic Toxoplasma gondii infection affects social behavior and neural circuits in female mice, identifying molecular changes in brain regions associated with social behavior.

No kissing in the nucleus: Unbiased analysis reveals no evidence of trans chromosomal regulation of mammalian immune development

The paper uses high-resolution genome-wide chromosome conformation capture to analyze transchromosomal interactions in immune cells and finds no evidence of gene regulatory transchromosomal interactions.