Wenmin Zhao

Detecting cell-level transcriptomic changes of Perturb-seq using Contrastive Fine-tuning of Single-Cell Foundation Models

The paper introduces a contrastive fine-tuning method for single-cell foundation models to detect subtle transcriptomic changes in Perturb-seq data, outperforming traditional differential expression methods.

Multi-modal single-cell foundation models via dynamic token adaptation

The paper introduces dynamic token adaptation to combine single-cell foundation models with DNA-sequence embeddings to predict gene regulation in different genetic contexts.

Pan-genome and Haplotype Map of Cultivars and Their Wild Ancestors Provides Insights into Adaptive Evolution of Cassava (Manihot esculenta Crantz)

The paper constructs nearly T2T genomes and a pan-genome of cassava cultivars and wild ancestors, revealing domestication genes and evolutionary insights.