Louwai Muhammed

TP53 and RB1 are predictive genetic biomarkers for sensitivity to cytarabine in gliomas

The paper identifies TP53 and RB1 wild-type status as predictors of cytarabine sensitivity in gliomas using CRISPRi screening and machine learning analysis.

Detecting cell-level transcriptomic changes of Perturb-seq using Contrastive Fine-tuning of Single-Cell Foundation Models

The paper introduces a contrastive fine-tuning method for single-cell foundation models to detect subtle transcriptomic changes in Perturb-seq data, outperforming traditional differential expression methods.

Multi-modal single-cell foundation models via dynamic token adaptation

The paper introduces dynamic token adaptation to combine single-cell foundation models with DNA-sequence embeddings to predict gene regulation in different genetic contexts.

Single-cell Mendelian randomisation identifies cell-type specific genetic effects on human brain disease and behaviour

The paper uses single-cell Mendelian randomisation to identify cell-type specific genetic effects on brain disease and behaviour, revealing 118 genes with causal associations to 16 brain phenotypes.