Dual cooperation between HSP70 and the 26S proteasome in co-translational protein quality control
Guiyou Tian, Cheng Hu, Yun Yun, Wensheng Yang, Wolfgang Dubiel, Yabin Cheng, Dieter A Wolf
This study identifies dual roles of HSPA1 in coordinating proteasome recruitment and maintaining ubiquitylated protein solubility during co-translational quality control, linking HSPH1 to cancer progression and prognosis.
bioRxiv · Jul 10, 2020 · PreprintBiochemistry