A novel broad-spectrum antibiotic targets multiple-drug-resistant bacteria with dual binding targets and no detectable resistance
Wenyan He, Xueting Huan, Yinchuan Li, Qisen Deng, Tao Chen, Wen Xiao, Yijun Chen, Lingman Ma, Nan Liu, Zhuo Shang, Zongqiang Wang
This paper discovers a novel antibiotic, paenimycin, that targets multiple-drug-resistant bacteria through a dual-binding mechanism and shows no detectable resistance.
Nature Communications · Jul 31, 2025Peer-reviewedBiochemistry