Yijun Chen

Intestinal molecular siphoning by engineered bacterial spores for non-systemic treatment of nicotine addiction

This paper develops a live bacterial system to reduce nicotine levels in blood and brain by enzymatic degradation in the gut, showing potential for non-systemic treatment of nicotine addiction.

Gene Conversion Directed Successive Engineering of Modular Polyketide Synthases

This paper describes a gene conversion-driven strategy to reprogram a modular PKS in the cinnamomycin biosynthetic gene cluster to generate a novel macrolide.

A novel broad-spectrum antibiotic targets multiple-drug-resistant bacteria with dual binding targets and no detectable resistance

This paper discovers a novel antibiotic, paenimycin, that targets multiple-drug-resistant bacteria through a dual-binding mechanism and shows no detectable resistance.

Pooled screening identifies combinatorial CAR signaling domains for next-generation CAR-M immunotherapies

The paper identifies combinatorial CAR signaling domains that enhance macrophage function and tumor clearance through pooled screening and single-cell analysis.

Comparative Analysis of the Techniques for the Determination of Binding Affinity between a Small Molecule Inhibitor and a Protein Target

This study compares KD values from SPR, ITC, and MST with Ki values from enzyme kinetics to assess their accuracy in determining binding affinity between small molecule inhibitors and protein targets.