Nan Liu

This paper introduces Borzoi-SE, a deep learning framework that identifies super-enhancers and detects pathogenic variants directly from DNA sequence across multiple human cell lineages.

This paper discovers a novel antibiotic, paenimycin, that targets multiple-drug-resistant bacteria through a dual-binding mechanism and shows no detectable resistance.

This study develops an age-prediction model using DNA methylation from a single ELOV2 genomic region, validated across cohorts and forensic applications.

The paper identifies IRF3 as a key transcriptional regulator of leptin's hunger-suppressing effects in AgRP neurons through integrated genomic analysis.

This study demonstrates high-efficiency HDR-mediated knock-in of large DNA fragments in human and mouse cell lines using crude rAAV without purification.

CUT&RUNTools processes CUT&RUN data to identify protein binding and genomic footprints through read analysis and visualization.

This study investigates age-related changes in FOXO transcription factor gene targeting in Drosophila melanogaster using ChIP-Seq, revealing a decline in FOXO-bound genes and shifts in targeted biological processes with age.

The paper introduces Screenlamp, a toolkit for hypothesis-driven ligand screening, and demonstrates its use in discovering GPCR inhibitors for invasive species control.