Tau conveys intrinsic hyperactivity of VTA dopamine neurons but an inability to sustain burst firing
William M. Kennedy, Eva Troyano‐Rodriguez, Matthew H. Higgs, Harris E. Blankenship, Anu Korukonda, David Weinshenker, Heather C. Rice, Michael J. Beckstead
The paper investigates the role of tau in VTA dopamine neuron dysfunction in Alzheimer's disease models, finding that tau induces hyperexcitability but impairs burst firing.
bioRxiv · Jul 28, 2025 · PreprintNeuroscience