Author

Matthew H. Higgs

Oklahoma Medical Research Foundation

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Assay:electronic health records· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Harris E. BlankenshipiD· 2 shared Michael J. BecksteadiD· 2 shared Anu KorukondaiD· 1 shared Arin PamukcuiD· 1 shared Brianna L. BerceauiD· 1 shared C. Savio ChaniD· 1 shared Charles J. WilsoniD· 1 shared David WeinshenkeriD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Harris E. BlankenshipORCID

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3 papers

Recent·Most cited

Tau conveys intrinsic hyperactivity of VTA dopamine neurons but an inability to sustain burst firing

William M. Kennedy, Eva Troyano‐Rodriguez, Matthew H. Higgs, Harris E. Blankenship, Anu Korukonda, David Weinshenker, Heather C. Rice, Michael J. Beckstead

The paper investigates the role of tau in VTA dopamine neuron dysfunction in Alzheimer's disease models, finding that tau induces hyperexcitability but impairs burst firing.

bioRxiv · Jul 28, 2025 · PreprintNeuroscience

PKC-dependent enhancement of glutamate input to VTA dopamine neurons in 3xTg-AD mice

Harris E. Blankenship, Matthew H. Higgs, Kylene M. Harold, Kenneth Michael Humphries, Michael J. Beckstead

The paper investigates synaptic input changes in VTA dopamine neurons of 3xTg-AD mice, finding enhanced excitatory input and reduced inhibition linked to PKC activity.

bioRxiv · Jul 24, 2025 · PreprintNeuroscience

Dissociable Roles of Pallidal Neuron Subtypes in Regulating Motor Patterns

Qiaoling Cui, Arin Pamukcu, Suraj Cherian, Isaac Y. M. Chang, Brianna L. Berceau, Harry S. Xenias, Matthew H. Higgs, Shivakumar Rajamanickam, Yi Chen, Xixun Du, Yu Zhang, Hayley E. McMorrow, Zachary A. Abecassis, Simina Maria Boca, Nicholas J. Justice, , C. Savio Chan

This study identifies distinct GPe neuron subtypes using mouse lines and shows their unique roles in motor behavior and anxiety-like behavior through optogenetics and machine learning.

Journal of Neuroscience · Mar 17, 2021Peer-reviewedNeuroscience