Comprehensive characterization of protein-protein interaction network perturbations by human disease mutations
Feixiong Cheng, Junfei Zhao, Yang Wang, Weiqiang Lü, Zehui Liu, Yadi Zhou, William Martin, Rui‐Sheng Wang, Jin Yan Huang, Tong Hao, Hong Yue, Jing Ma, Yuan Hou, Jessica A. Castrillon, Jiansong Fang, , Joseph Loscalzo
This study identifies disease mutations that perturb protein-protein interactions in the human 3D interactome, showing their association with cancer survival and drug response.
bioRxiv · Sep 18, 2020 · PreprintSystems Biology