Yang Wang

This study shows quercetin enhances thermogenesis in brown adipocytes by upregulating UCP1 and activates the COX2-PGE2-EP4-UCP1 signaling pathway, improving glucose and lipid metabolism.

TREND identifies context-specific enhancers for targeted immunotherapy by analyzing TF-responsive enhancer libraries in ovarian cancer.

The paper investigates how dual-role regulators interact with the Sin3 complex using structural and functional analyses, revealing mechanisms for transcriptional crosstalk.

This paper introduces MR-APSS, a Mendelian Randomization method that addresses pleiotropy and sample structure to improve causal inference from GWAS summary statistics.

This study identifies disease mutations that perturb protein-protein interactions in the human 3D interactome, showing their association with cancer survival and drug response.

The paper creates a proactive map of CBS gene variant function and vitamin B6 response using yeast assays, predicting disease severity and therapy effectiveness.

This study uses Oxford Nanopore long-read sequencing to precisely localize breakpoints in balanced translocations and inversions, achieving single-base resolution for some cases.

The paper presents HuRI, a comprehensive human protein-protein interaction map, and demonstrates its utility in understanding cellular function and disease mechanisms.

The paper identifies a risk variant in the miR-544a binding site of CCDC170 associated with osteoporosis by showing miR-544a regulates osteogenesis and osteoclastogenesis through target genes.