Yadi Zhou

γ-aminobutyric acid receptor B signaling drives glioblastoma in females in an immune-dependent manner

This study shows GABA receptor B signaling promotes GBM growth in females through immune mechanisms, with sex-specific effects on survival and treatment outcomes.

Interactome mapping in human excitatory neurons reveals novel risk genes and pathways in Alzheimer's disease

The paper develops a neuron-specific interactome map in human excitatory neurons to identify novel risk genes and pathways in Alzheimer's disease.

Dysregulation of innate immunity and cellular metabolism through virus-induced deISGylation

This study shows that SARS-CoV-2 deISGylation by PLpro suppresses innate immunity and promotes viral replication by modulating cellular metabolism.

Structurally-informed human interactome reveals proteome-wide perturbations by disease mutations

The paper introduces PIONEER, a deep learning framework for predicting protein-protein interfaces, and shows disease mutations are enriched in these interfaces, identifying oncoPPIs linked to cancer survival and drug responses.

Comprehensive characterization of multi-omic landscapes between gut-microbiota metabolites and the G-protein-coupled receptors in Alzheimer's disease

This study identifies GPCR targets of gut microbiota metabolites in Alzheimer's disease using multi-omics and machine learning.

Peripheral sTREM2-related inflammatory activity alterations in early stage Alzheimer's disease

This study examines the relationship between sTREM2 and inflammatory activity in early stage Alzheimer's disease using clinical and biomarker-defined groups.

SOAR elucidates disease mechanisms and empowers drug discovery through spatial transcriptomics

SOAR provides a curated spatial transcriptomics database and analysis tools to facilitate disease mechanism studies and drug discovery.

PlantNexus: A Gene Co-expression Network Database and Visualization Tool for Barley and Sorghum

The paper constructs gene co-expression networks for barley and sorghum using RNA-seq data and provides a database and visualization tool called PlantNexus.

A Network-based Deep Learning Framework Catalyzes GWAS and Multi-Omics Findings to Biology and Drug Repurposing for Alzheimer's Disease

This paper introduces a network-based deep learning framework to translate GWAS findings into biological insights and drug targets for Alzheimer's disease, identifying 156 putative risk genes.

Network-based prediction and functional validation of metformin for potential treatment of atrial Fibrillation using human inducible pluripotent stem cell-derived atrial-like cardiomyocytes

This study uses network-based methods to identify and validate metformin as a potential treatment for atrial fibrillation using human-derived atrial-like cardiomyocytes.

Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

This study links SARS-CoV-2 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment through network-based genomics analysis.

Multimodal single-cell/nucleus RNA-sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer's disease

AlzGPS: A Genome-wide Positioning Systems Platform to Catalyze Multi-omics for Alzheimer's Therapeutic Discovery

AlzGPS integrates multi-omics data and networks to identify repurposable drugs for Alzheimer's disease.

Multimodal Single-Cell Omics Analysis of COVID-19 Sex Differences in Human Immune Systems

The paper examines sex differences in COVID-19 outcomes and immune responses using single-cell RNA-sequencing and clinical data, finding higher risk for males and potential mechanisms for sex-specific treatments.

Comprehensive characterization of protein-protein interaction network perturbations by human disease mutations

This study identifies disease mutations that perturb protein-protein interactions in the human 3D interactome, showing their association with cancer survival and drug response.