Junfei Zhao

MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, enhances tumor-microglia crosstalk, and drives immune checkpoint blockade efficacy.

This study identifies the MAPK/ERK pathway as a key regulator of glioma susceptibility to immune checkpoint blockade, showing it modulates interferon responses, T cell recruitment, and tumor-microglia interactions.

A transposase-derived gene required for human brain development

This study identifies PGBD5 as a transposase-derived gene essential for brain development in humans and mice, with deficiency causing intellectual disability and seizures.

Mechanisms of insertions at a DNA double-strand break

The paper develops Indel-Seq to study insertion mechanisms at DNA double-strand breaks, finding insertions arise from transcription and require DNA-PK and ssDNA overhangs.

ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion.

This study shows ATR kinase prevents replication resource exhaustion in early S phase, supporting normal cell proliferation by regulating origin firing.

Structurally-informed human interactome reveals proteome-wide perturbations by disease mutations

The paper introduces PIONEER, a deep learning framework for predicting protein-protein interfaces, and shows disease mutations are enriched in these interfaces, identifying oncoPPIs linked to cancer survival and drug responses.

ARP2/3- and resection-coupled genome reorganization facilitates translocations

The paper shows that ARP2/3-dependent nuclear actin polymerization and DNA end-resection coordinate genome reorganization to facilitate homology-directed repair and prevent translocations.

Comprehensive characterization of protein-protein interaction network perturbations by human disease mutations

This study identifies disease mutations that perturb protein-protein interactions in the human 3D interactome, showing their association with cancer survival and drug response.