Charis Eng

NeuroPupil: A generalization-first framework for scalable and biologically informative cross-species pupillometry

NeuroPupil improves cross-species pupillometry with a deep learning framework, achieving better accuracy and efficiency while enabling reliable biological insights.

Breast tumor microbiome regulates anti-tumor immunity and T cell-associated metabolites

This study investigates how the breast tumor microbiome interacts with CD8+ TILs and metabolites, showing that Staphylococcus influences anti-tumor immunity and T cell-associated metabolites.

Altered primary somatosensory neuron development in a Pten heterozygous model for autism spectrum disorder

This study examines sensory behaviors and transcriptomic changes in a Pten heterozygous mouse model of ASD, identifying altered somatosensory neuron development and subtype-specific marker expression.

Neurobehavioral Signatures in Overgrowth Intellectual Disability Syndromes: Dissecting Genotype-Phenotype Relationships in the PI3K-AKT-MTOR Pathway

The paper compares neurobehavioral profiles of Smith-Kingsmore Syndrome and PTEN Hamartoma Tumor Syndrome, identifying distinct features and diagnostic markers.

Structurally-informed human interactome reveals proteome-wide perturbations by disease mutations

The paper introduces PIONEER, a deep learning framework for predicting protein-protein interfaces, and shows disease mutations are enriched in these interfaces, identifying oncoPPIs linked to cancer survival and drug responses.

Redefining the PTEN Promoter: Identification of Two Upstream Transcription Start Regions

The paper identifies two new transcription start regions (TSRs) upstream of the PTEN promoter, expanding its regulatory landscape and suggesting potential clinical implications for PTEN-related disorders.

The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane

This study uses explicit solvent simulations to reveal how PTEN interacts with phosphoinositide-enriched membranes, elucidating its mechanism of activation and membrane anchoring.

Multimodal Single-Cell Omics Analysis of COVID-19 Sex Differences in Human Immune Systems

The paper examines sex differences in COVID-19 outcomes and immune responses using single-cell RNA-sequencing and clinical data, finding higher risk for males and potential mechanisms for sex-specific treatments.

Comprehensive characterization of protein-protein interaction network perturbations by human disease mutations

This study identifies disease mutations that perturb protein-protein interactions in the human 3D interactome, showing their association with cancer survival and drug response.

An integrated deep mutational scanning approach provides clinical insights on PTEN genotype-phenotype relationships

This study combines deep mutational scanning data with clinical data to link PTEN variants to specific clinical outcomes and risk levels.