Cell invasive amyloid assemblies from SARS-CoV-2 peptides can form multiple polymorphs with varying neurotoxicity
Oana Sanislav, Rina Tetaj, Metali, Julian Ratcliffe, William Phillips, Annaleise R. Klein, Ashish Sethi, Jiangtao Zhou, Raffaele Mezzenga, Sina S. Saxer, Mirren Charnley, Sarah J. Annesley, Nicholas P. Reynolds
This study investigates how SARS-CoV-2 peptides form amyloid assemblies with varying neurotoxicity and polymorphic structures, showing that aggregation conditions influence toxicity and cellular uptake.
bioRxiv · May 16, 2024Biophysics