Author

William T. J. Hendriks

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

D. Cristopher BraggiD· 3 shared Aloysius DomingoiD· 2 shared Benjamin CurralliD· 2 shared Dadi GaoiD· 2 shared Laurie J. OzeliusiD· 2 shared Michael E. TalkowskiiD· 2 shared Nutan SharmaiD· 2 shared Rachita YadaviD· 2 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

D. Cristopher BraggORCID

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Author profile →

3 papers

Recent·Most cited

Variation in TAF1 expression in female carrier induced pluripotent stem cells and human brain ontogeny has implications for adult neostriatum vulnerability in X-linked Dystonia Parkinsonism

Laura D’Ignazio, Ricardo de Souza Jacomini, Bareera Qamar, Kynon JM Benjamin, Ria Arora, Tomoyo Sawada, Taylor A. Evans, Kenneth E. Diffenderfer, Aimee R. Pankonin, William T. J. Hendriks, Thomas M. Hyde, Joel E. Kleinman, Daniel R. Weinberger, D. Cristopher Bragg, Apuã C.M. Paquola, Jennifer A. Erwin

This study characterizes TAF1 expression variation in XDP female carriers and human brain ontogeny, identifying age- and region-specific patterns that may explain neostriatum vulnerability in XDP.

eNeuro · Jul 1, 2022Peer-reviewedNeuroscience

Dystonia-specific mutations in THAP1 alter transcription of genes associated with neurodevelopment and myelin

Aloysius Domingo, Rachita Yadav, Shivangi Shah, William T. J. Hendriks, Serkan Erdin, Dadi Gao, Kathryn O’Keefe, Benjamin Currall, James F. Gusella, Nutan Sharma, Laurie J. Ozelius, Michelle E. Ehrlich, Michael E. Talkowski, D. Cristopher Bragg

The paper investigates how dystonia-specific mutations in THAP1 affect gene transcription related to neurodevelopment and myelin in iPSC-derived neural cells and mouse models.

The American Journal of Human Genetics · Oct 21, 2021Peer-reviewedGenetics

Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly

Tatsiana Aneichyk, William T. J. Hendriks, Rachita Yadav, David S. Shin, Dadi Gao, Christine A. Vaine, Ryan L. Collins, Aloysius Domingo, Benjamin Currall, Alexei Stortchevoi, Trisha Multhaupt‐Buell, Ellen B. Penney, Lilian Cruz, Jyotsna Dhakal, Harrison Brand, , Michael E. Talkowski

This study identifies the causal mechanism of X-linked Dystonia-Parkinsonism (XDP) by integrating genome and transcriptome assembly, revealing a SVA insertion causing intron retention and TAF1 dysfunction.

Cell · Jan 1, 2018Peer-reviewedGenomics