David Shin

This study shows that TS21 accelerates radial glia lineage progression, leading to premature production of inhibitory neurons and oligodendrocytes in Down syndrome.

The paper introduces a method to map neuronal circuits using barcoded rabies virus and single-nucleus RNA sequencing, revealing cell-type-specific circuit motifs in developing human cerebral cortex.

The paper uses single cell and spatial transcriptomics to study thalamic development in humans, identifying molecular mechanisms of nuclei formation and neuron subtypes.

This study investigates rubella virus tropism in human brain slices and organoids, showing microglia as the primary target and revealing an interferon response in non-microglial cells.

The paper examines how rare and common genomic variants affect brain functional connectivity, revealing how polygenicity and pleiotropy influence psychiatric conditions and brain networks.

This study maps human microglia development and identifies cytokine-associated subtypes and functional roles in neural network maturation.

This study identifies the causal mechanism of X-linked Dystonia-Parkinsonism (XDP) by integrating genome and transcriptome assembly, revealing a SVA insertion causing intron retention and TAF1 dysfunction.