Recapitulating Patient-to-Patient Colorectal Cancer Tumor Heterogeneity Using Patient-Derived Xenograft Cells in an Engineered Tissue Model
Iman Hassani, Benjamin Anbiah, Yuan Tian, Bulbul Ahmed, William Van Der Pol, Elliot J. Lefkowitz, Peyton C. Kuhlers, Nicole L. Habbit, Martin J. Heslin, Michael W. Greene, Elizabeth A. Lipke
This study develops 3D-eCRC-PDX tissues to recapitulate patient-specific tumor heterogeneity, showing they maintain growth rates, cell subpopulations, mechanical stiffness, and gene expression profiles.
Acta Biomaterialia · Feb 27, 2026Peer-reviewedBioengineering