Peyton C. Kuhlers

Arginine methylation of BAF155 regulates interactions with RNA processing machinery

The paper shows that arginine methylation of BAF155 enhances its interaction with RNA processing factors, affecting nascent transcription at promoters.

Recapitulating Patient-to-Patient Colorectal Cancer Tumor Heterogeneity Using Patient-Derived Xenograft Cells in an Engineered Tissue Model

This study develops 3D-eCRC-PDX tissues to recapitulate patient-specific tumor heterogeneity, showing they maintain growth rates, cell subpopulations, mechanical stiffness, and gene expression profiles.

Menin-MLL1 complex cooperates with NF-Y to promote HCC survival

This study identifies the menin-MLL1 complex as essential for HCC survival and shows it cooperates with NF-Y to regulate oncogenic gene transcription.

BAP1 deletion in hepatocytes primes an inflammatory transcriptional response

This study shows that BAP1 deletion in hepatocytes leads to an inflammatory transcriptional response and impaired immune cell recruitment in the liver.

Sub-Cluster Identification through Semi-SupervisedOptimization of Rare-cell Silhouettes (SCISSORS) in Single-Cell Sequencing

SCISSORS identifies rare cell types in scRNA-seq data through semi-supervised reclustering and marker gene detection.