HSC70 prevents TDP-43 nuclear puncta formation and toxicity in a novel nuclear puncta cell model for ALS
Wu Jp, Shin-Yu Fan, Tien‐Hsien Chang, Yun‐Ru Chen
This paper identifies a TDP-43 mutation, G148V, that causes nuclear puncta formation and toxicity, and shows HSC70 prevents this pathology in a cellular model of ALS.
bioRxiv · Jul 23, 2026 · PreprintCell Biology