Tien‐Hsien Chang

This paper identifies a TDP-43 mutation, G148V, that causes nuclear puncta formation and toxicity, and shows HSC70 prevents this pathology in a cellular model of ALS.

The paper identifies 96 yeast host genes essential for L-A virus maintenance and shows the virus enhances host stress tolerance, revealing a mutualistic relationship.

This paper identifies a conserved unstructured region in Prp40 WW domains that facilitates their positioning to promote non-canonical intron splicing in yeast.