Yan Zhang

This study shows that Cbfβ deficiency leads to OA by altering Wnt/β-catenin, Hippo/Yap, and TGFβ signaling, and that local Cbfβ overexpression protects against OA in mice.

The paper identifies key genes involved in NCSC adipogenesis through mRNA sequencing, RT-qPCR, and RNAi, revealing a positive feedback loop between C/EBPβ and PPARγ.

This study shows MACF1 is essential for bone formation by enabling SMAD7 nuclear translocation in MSCs, leading to ossification retardation and bone loss in mice.

The paper resolves the classification of two GJB2 variants as pathogenic for autosomal recessive nonsyndromic hearing loss through expert consensus.