Lei Chen

EPIP: MHC-I epitope prediction integrating mass spectrometry derived motifs and tissue-specific expression profiles

EPIP predicts MHC-I epitope presentation by integrating mass spectrometry-derived motifs and tissue-specific RNA-seq data, outperforming existing methods in independent validation.

The origin of domestication genes in goats

This study identifies introgression and selection events in goat domestication, linking them to immune and behavioral genes.

Selective targeting of an oncogenic KRAS mutant allele by CRISPR/Cas9 induces efficient tumor regression

This paper develops CRISPR systems to target and deplete an oncogenic KRAS mutant allele, leading to tumor regression in vitro and in vivo.

MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation in Mice

This study shows MACF1 is essential for bone formation by enabling SMAD7 nuclear translocation in MSCs, leading to ossification retardation and bone loss in mice.

A Whole-Genome Association Approach for Large-scaled Inter-species Trait

The paper introduces a whole-genome association approach using kmer frequencies to study large-scale inter-species traits, applying it to chromosome number in mammalian proteomes and identifying candidate genes.

Draft genome of the Reindeer (Rangifer tarandus)

The paper presents the first high-quality reference genome of the reindeer, providing insights into its evolution and unique biological features.