Effects of individual base-pairs on in vivo target search and destruction kinetics of small RNA
Anustup Poddar, Muhammad S. Azam, Tunc Kayikcioglu, Maksym Bobrovskyy, Jichuan Zhang, Xiangqian Ma, Piyush Labhsetwar, Jingyi Fei, Digvijay Singh, Zaida Ann Luthey-Schulten, Carin K. Vanderpool, Taekjip Ha
This study investigates how single base-pair changes affect the in vivo kinetics of sRNA-target interactions, showing that Hfq facilitates annealing and buffers base-pair disruptions.
Nature Communications · Feb 8, 2021Peer-reviewedMolecular Biology