Author
University of Illinois Urbana-ChampaignORCID 0000-0001-9749-8367Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
TIANYU WU, Marie-Christin Spindler, Abner T. Apsley, Emmy Earnest, Zane R. Thornburg, Julia Mahamid, Zaida Ann Luthey-Schulten
The paper develops spatially-resolved models of the yeast galactose switch to show how intracellular organization affects regulatory dynamics.
PLoS Computational Biology · Oct 5, 2026Peer-reviewedSystems Biology
Zane R. Thornburg, Andrew K. Maytin, Jiwoong Kwon, Troy A. Brier, Benjamin R. Gilbert, Enguang Fu, Yang-le Gao, Jordan Quenneville, Tianyu Wu, Henry Li, Talia Long, Weria Pezeshkian, Lijie Sun, DANIELA MATIAS DE CARVALHO BITTENCOURT, John I. Glass, , Zaida Ann Luthey-Schulten
A hybrid 4D whole-cell simulation of the minimal bacterium JCVI-syn3A integrates spatial reaction-diffusion, metabolism, polymer chromosome dynamics, and division across a complete 105-minute cell cycle.
Cell · Mar 9, 2026Peer-reviewedBiophysics✦ In-depth digest
Enguang Fu, Zane R. Thornburg, Troy A. Brier, Rong Wei, Bo Yuan, Benjamin R. Gilbert, Shulei Wang, Zaida Ann Luthey-Schulten
The paper integrates the assembly of 21 macromolecular complexes into a whole-cell kinetic model of JCVI-syn3A, improving efficiency and consistency with experimental data.
The Journal of Physical Chemistry B · Dec 22, 2025Peer-reviewedBiophysics
Bo Yuan, Rong Wei, Troy A. Brier, Enguang Fu, Zane R. Thornburg, Zaida Ann Luthey-Schulten, Shulei Wang
COTree is a statistical framework that analyzes multi-omic simulation trajectories to identify cellular progression patterns and key driver species in a whole-cell model.
bioRxiv · Oct 30, 2025 · PreprintBioinformatics
Troy A. Brier, Jason E. Cournoyer, Benjamin R. Gilbert, Sage A. Glass, Yang-le Gao, Yanbao Yu, Zane R. Thornburg, Karrie C. Goglin, Gavin John, Tiana Mamaghani, Sujata Shivakumar, Christopher J. Fields, John I. Glass, Angad P. Mehta, Zaida Ann Luthey-Schulten
This study compares transcriptomes of two minimized bacteria to understand gene expression patterns and highlights limitations of bioinformatics alone.
bioRxiv · Oct 23, 2025 · PreprintSynthetic Biology
Anustup Poddar, Muhammad S. Azam, Tunc Kayikcioglu, Maksym Bobrovskyy, Jichuan Zhang, Xiangqian Ma, Piyush Labhsetwar, Jingyi Fei, Digvijay Singh, Zaida Ann Luthey-Schulten, Carin K. Vanderpool, Taekjip Ha
This study investigates how single base-pair changes affect the in vivo kinetics of sRNA-target interactions, showing that Hfq facilitates annealing and buffers base-pair disruptions.
Nature Communications · Feb 8, 2021Peer-reviewedMolecular Biology