Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel
Anna K. Koster, Austin L. Reese, Yuri A. Kuryshev, Xianlan Wen, Keri A. McKiernan, Erin E. Gray, Caiyun Wu, John R. Huguenard, Merritt C. Maduke, J. Du Bois
The paper develops and validates AK-42, a potent and specific inhibitor of CLC-2 chloride channels with nanomolar potency and high selectivity.
Proceedings of the National Academy of Sciences · Dec 4, 2020Peer-reviewedNeuroscience