John R. Huguenard

This study creates human neuromodulatory assembloids to investigate serotonin signaling and disease mechanisms, showing altered 5-HT dynamics in 22q11.2DS and rescue with SSRIs.

The paper identifies a dual inhibitory network in the thalamic reticular nucleus (TRN) involving intra-TRN and pallidal inputs, revealing subtype-specific connectivity and complementary mechanisms for thalamic signal gating.

The paper investigates cognitive deficits in absence epilepsy by examining thalamic-prefrontal circuit dysfunction in a mouse model, finding impaired reversal learning and identifying potential therapeutic targets.

The paper uses interpretable machine learning to derive dynamical equations from seizure data, revealing a chaotic attractor mechanism in thalamocortical circuits that drives absence seizures.

This study identifies reticular thalamic hyperexcitability as a driver of ASD behaviors in Cntnap2 knockout mice and shows that targeting RT activity can alleviate these deficits.

This study investigates how carbamazepine (CBZ) affects thalamic reticular neurons, revealing it selectively inhibits their tonic firing and disrupts GABAergic transmission, which exacerbates absence seizures.

The paper identifies Cdh6 as a marker for a novel class of sensory neurons in the mouse colon that regulate colonic motility through specific electrophysiological properties and functional responses.

This study investigates the functional connectivity of the Reuniens nucleus to the medial prefrontal cortex, revealing prolonged recurrent excitation and potential roles in memory formation.

This study examines early synaptic and network disruptions in the mPFC and its projections to the MD in Shank3-/- mice, showing that synaptic deficits precede behavioral deficits and contribute to later dysfunction.

The paper investigates fast neural coordination across brain regions during autobiographical memory processing using intracranial recordings in humans.

This study identifies molecular foci of brain aging in mice using spatiotemporal RNA-seq, showing accelerated glial aging in white matter and differential gene expression linked to neurodegenerative diseases.

This study uses human assembloids to investigate how CACNA1G gene variants affect thalamocortical pathway function in neuropsychiatric disorders.

The paper investigates the role of prefrontal parvalbumin interneurons in attention and links their dysfunction to attentional impairments in a mouse model of absence epilepsy.

This study develops a photocaged saxitoxin derivative to precisely control voltage-gated sodium channel blockade and demonstrates its effects on action potential propagation in neurons.

The paper develops and validates AK-42, a potent and specific inhibitor of CLC-2 chloride channels with nanomolar potency and high selectivity.

This paper uses machine learning models to predict epileptic seizures in mice, achieving 98% accuracy with logistic regression and convolutional neural networks.

The paper shows that blocking both GAT1 and GAT3 suppresses thalamocortical oscillations, revealing nonlinear regulation of T-type calcium channels by GABAB receptor activity.

This study shows that maladaptive myelination driven by absence seizures contributes to epileptogenesis in two mouse models of absence epilepsy.

The paper identifies pre-seizure thalamic activity patterns in absence epilepsy that vary across seizures and may improve seizure prediction.