Merritt C. Maduke

The paper investigates how BIM1 selectively inhibits CLC-Ka over CLC-Kb by analyzing cryo-EM structures and showing that interactions with a conserved lysine and dynamic gating-loop behavior underlie this selectivity.

The paper provides a mechanistic model for the 2:1 Cl-/H+ exchange in CLC transporters using structural and computational methods.

The paper develops and validates AK-42, a potent and specific inhibitor of CLC-2 chloride channels with nanomolar potency and high selectivity.

This study shows ultrasound can inhibit or potentiate firing in hippocampal neurons depending on firing frequency, explained by increased potassium conductance.

The paper investigates how ultrasound at 43 MHz affects Piezo1 and NaV1.2 channels, finding that Piezo1 is activated by acoustic streaming while NaV1.2 is not directly affected but may be influenced by heating.