J. Du Bois

This study shows that RcSxph from American bullfrogs can counteract saxitoxin poisoning in mice by binding the toxin, validating its role as a toxin sponge.

This study identifies saxiphilin as a toxin sponge that binds multiple C13-modified saxitoxin congeners, revealing structural adaptability and conformational plasticity in toxin-protein interactions.

This paper develops a chemogenetic tool to selectively inhibit specific voltage-gated sodium channel subtypes with high precision and reversibility.

This paper identifies the structural basis for saxitoxin congener binding and neutralization by saxiphilins, showing how these proteins sequester toxins and reverse sodium channel blockage.

This study shows that clock genes in nociceptors affect pain sensitivity differently in males and females across times of day.

This paper introduces a method to reversibly control neuronal activity using a light-activated saxitoxin inhibitor, demonstrating its effectiveness in altering behavior in zebrafish without genetic modification.

This study shows Schwann cells promote sensory neuron excitability during development by secreting prostaglandin E2, which is essential for normal sodium channel expression and action potential firing.

This study develops a photocaged saxitoxin derivative to precisely control voltage-gated sodium channel blockade and demonstrates its effects on action potential propagation in neurons.

The paper develops and validates AK-42, a potent and specific inhibitor of CLC-2 chloride channels with nanomolar potency and high selectivity.

This paper describes the discovery of ST-2262, a selective NaV1.7 inhibitor with state-independent action, showing reduced pain sensitivity in non-human primates.