Social isolation recruits amygdala-medial prefrontal cortex projections to escalate alcohol drinking in male mice
Reesha R. Patel, Kelly N. Kim, Makenzie Patarino, Rachelle Pamintuan, Felix Taschbach, Hao Li, Bitna Joo, Anna Pallé, Xianru Yu, Christopher R. Lee, Aniek van Hoek, Jesse White, Rogelio Castro, Christian Cazares, Raymundo L Miranda, , Kay M. Tye
This study identifies a BLA-mPFC neural pathway through which social isolation increases alcohol drinking in male mice by altering prefrontal cortex activity.
Nature Neuroscience · Aug 25, 2026Peer-reviewedNeuroscience